Reema A. Al-Eryani, Ghada A. El-Baz, Wael M. Abd-Alkhalek, Essam M. Abd-Allahand Mohamed Sherif M. Salah El-Din,

ABSTRACT
Aim Of The Study: To Study The Variations In Some Salivary Parameters (pH, Ca2+, SIgA, And Lysozyme) And Their Influence On Dental Caries Status In Egyptian And Yemenis Asthmatic Children. Subjects And Methods: This Study Was Carried Out On Two Hundred Children Of Both Sexes With Age Ranged From 6-10 Years. The Cases Were Divided Into Two Main Groups; One Hundred Children From Egypt And One Hundred Children From Yemen. Each Group Was Subdivided Into Two Subgroups; Fifty Children Asthmatic And Fifty Children Healthy. Dental Caries Was Assessed For Each Child According To WHO Criteria (1997) For Detection Of Caries Using DMFS For Permanent Dentition. Saliva Samples Were Collected From Each Child To Measure: PH, Ca2+, SIgA, And Lysozyme. The Correlation Between Different Salivary Parameters And Dental Caries In Permanent Dentition Was Evaluated.

Results: Asthmatic Children Showed No Significant Differences In All Studied Variables Between Egyptian And Yemeni Children. While For Healthy Children, Egyptians Showed Statistically Significant Higher Mean PH Level And Lower Mean Ca2+ And Lysozyme Levels Than Yemeni Children. In Comparing Between Asthmatic And Healthy Children, Egyptian Asthmatic Children Showed Statistically Significant Lower Mean PH Level And Higher Mean Ca2+, SIgA, And Lysozyme Levels Than Healthy Children. Regarding Yemeni Asthmatic Children, There Were Statistical Significant Higher Mean PH And Lysozyme Levels And Lower DMFS Score Than Healthy Children. Egyptian Healthy Children Showed A Statistically Significant Positive Correlation Between DMFS Score And SIgA Levels. Regarding Yemeni Asthmatic Group, There Was A Statistically Significant Positive Correlation Between DMFS Score And SIgA And Negative Correlation Between DMFS Score And Ca2+ Level. While The Yemeni Healthy Children Showed A Positive Correlation Between DMFS Score And SIgA. ROC Curve Analysis Showed That Saliva Samples Of Children With Lysozyme Above 5.80 Ng/ml And 4.66ng/ml For Egyptian And Yemenis Respectively, Can Be Suspected For Asthma With Accuracy Of 66% And 64% In Both Groups Respectively. Conclusion: Salivary Analysis Revealed An Overall Altered Salivary Composition In Children With Asthma, Indicating A Compromised Oral Environment In These Patients And Suggesting Salivary Analysis As An Additional Diagnostic Tool For Allergic Diseases.